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An in vitro study of neutrophil chemotaxis
When, at the beginning of 1972, my scientific attention was first drawn to the subject of cellular participation in the inflanunatory response, I was struck by the need for an understanding of the cellular and molecular mechanisms whereby blood leucocytes are attracted to an area of injury. The lite...
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| Format: | Thesis |
| Language: | English |
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Department of Human Biology
2020
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| _version_ | 1867613181740843008 |
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| access_status_str | Open Access |
| author | Todd, Gail |
| author2 | Dowdle, E B |
| author_browse | Dowdle, E B Todd, Gail |
| author_facet | Dowdle, E B Todd, Gail |
| author_sort | Todd, Gail |
| collection | Thesis |
| description | When, at the beginning of 1972, my scientific attention was first drawn to the subject of cellular participation in the inflanunatory response, I was struck by the need for an understanding of the cellular and molecular mechanisms whereby blood leucocytes are attracted to an area of injury. The literature at that time contained good technical accounts of methods available for studying chemotaxis in vitro and many reports of diverse compounds of biological origin with attractant, or chemotactic, properties for motile, phagocytic cells. In general, these reports tended to substantiate the belief that chemical substances generated at an inflannnatory source attracted cells to that source in a teleologically appropriate way and they justified, by the consistent correlation observed, the relevance of in vitro procedures for studying the phenomenon. In other words, answers were available to the question "What substances attract?"; very few were available to the question, "How do they attract?". |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/31946 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:03.909Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Department of Human Biology |
| publisherStr | Department of Human Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/31946 An in vitro study of neutrophil chemotaxis Todd, Gail Dowdle, E B Neutrophils chemotaxis leucocytes When, at the beginning of 1972, my scientific attention was first drawn to the subject of cellular participation in the inflanunatory response, I was struck by the need for an understanding of the cellular and molecular mechanisms whereby blood leucocytes are attracted to an area of injury. The literature at that time contained good technical accounts of methods available for studying chemotaxis in vitro and many reports of diverse compounds of biological origin with attractant, or chemotactic, properties for motile, phagocytic cells. In general, these reports tended to substantiate the belief that chemical substances generated at an inflannnatory source attracted cells to that source in a teleologically appropriate way and they justified, by the consistent correlation observed, the relevance of in vitro procedures for studying the phenomenon. In other words, answers were available to the question "What substances attract?"; very few were available to the question, "How do they attract?". 2020-05-20T09:50:43Z 2020-05-20T09:50:43Z 1976 2020-04-14T11:20:22Z Doctoral Thesis Doctoral https://hdl.handle.net/11427/31946 eng application/pdf Department of Human Biology Faculty of Health Sciences |
| spellingShingle | Neutrophils chemotaxis leucocytes Todd, Gail An in vitro study of neutrophil chemotaxis |
| thesis_degree_str | Doctoral |
| title | An in vitro study of neutrophil chemotaxis |
| title_full | An in vitro study of neutrophil chemotaxis |
| title_fullStr | An in vitro study of neutrophil chemotaxis |
| title_full_unstemmed | An in vitro study of neutrophil chemotaxis |
| title_short | An in vitro study of neutrophil chemotaxis |
| title_sort | in vitro study of neutrophil chemotaxis |
| topic | Neutrophils chemotaxis leucocytes |
| url | https://hdl.handle.net/11427/31946 |
| work_keys_str_mv | AT toddgail aninvitrostudyofneutrophilchemotaxis AT toddgail invitrostudyofneutrophilchemotaxis |