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The role of peptides as intermediates in protein metabolism
There is much evidence in the recent literature that peptides may be intermediates in normal protein biosynthesis. This has also been inferred from certain disease states and other conditions under which protein biosynthesis is blocked at some point, e.g. cadmium, amino acid analogues or (in bacter...
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| Format: | Thesis |
| Language: | English |
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Department of Pathology
2020
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| _version_ | 1867613339601862656 |
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| access_status_str | Open Access |
| author | Berman, Mervyn Clive |
| author2 | Kench, J E |
| author_browse | Berman, Mervyn Clive Kench, J E |
| author_facet | Kench, J E Berman, Mervyn Clive |
| author_sort | Berman, Mervyn Clive |
| collection | Thesis |
| description | There is much evidence in the recent literature that peptides may be intermediates in normal protein biosynthesis.
This has also been inferred from certain disease states and other conditions under which protein biosynthesis is blocked at some point, e.g. cadmium, amino acid analogues or (in bacteria) antibiotics. The literature covering this concept will be presented. The present studies have been carried out on children, who because they are suffering from chronic protein malnutrition have very much lowered rates of protein synthesis and breakdown. In this unfortunate, but natural experiment, it was hoped that some factor or factors derived from protein synthesis might be found which influenced the synthetic mechanism as a whole. Evidence from the literature has been summarized which concludes that urine, apart from being convenient to collect, is the biological fluid most likely to contain high concentrates of peptides which are released during cellular metabolism. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/31984 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:33.896Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Department of Pathology |
| publisherStr | Department of Pathology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/31984 The role of peptides as intermediates in protein metabolism Berman, Mervyn Clive Kench, J E Peptides protein biosynthesis There is much evidence in the recent literature that peptides may be intermediates in normal protein biosynthesis. This has also been inferred from certain disease states and other conditions under which protein biosynthesis is blocked at some point, e.g. cadmium, amino acid analogues or (in bacteria) antibiotics. The literature covering this concept will be presented. The present studies have been carried out on children, who because they are suffering from chronic protein malnutrition have very much lowered rates of protein synthesis and breakdown. In this unfortunate, but natural experiment, it was hoped that some factor or factors derived from protein synthesis might be found which influenced the synthetic mechanism as a whole. Evidence from the literature has been summarized which concludes that urine, apart from being convenient to collect, is the biological fluid most likely to contain high concentrates of peptides which are released during cellular metabolism. 2020-05-22T17:29:07Z 2020-05-22T17:29:07Z 1964 2020-04-06T17:38:47Z Doctoral Thesis Doctoral https://hdl.handle.net/11427/31984 eng application/pdf Department of Pathology Faculty of Health Sciences |
| spellingShingle | Peptides protein biosynthesis Berman, Mervyn Clive The role of peptides as intermediates in protein metabolism |
| thesis_degree_str | Doctoral |
| title | The role of peptides as intermediates in protein metabolism |
| title_full | The role of peptides as intermediates in protein metabolism |
| title_fullStr | The role of peptides as intermediates in protein metabolism |
| title_full_unstemmed | The role of peptides as intermediates in protein metabolism |
| title_short | The role of peptides as intermediates in protein metabolism |
| title_sort | role of peptides as intermediates in protein metabolism |
| topic | Peptides protein biosynthesis |
| url | https://hdl.handle.net/11427/31984 |
| work_keys_str_mv | AT bermanmervynclive theroleofpeptidesasintermediatesinproteinmetabolism AT bermanmervynclive roleofpeptidesasintermediatesinproteinmetabolism |