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On the humoral mediation of the intestinal phase of gastric secretion
The existence of a stimulatory intestinal phase of gastric acid secretion has been suspected for some time, and recently the importance of this phase has been recognized. The intestinal phase is of particular interest in relation to the profound gastric hypersecretion associated with portacaval anas...
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| Format: | Thesis |
| Language: | English |
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Department of Medicine
2020
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| _version_ | 1867613212200927232 |
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| access_status_str | Open Access |
| author | Kester, Ralph Charles |
| author_browse | Kester, Ralph Charles |
| author_facet | Kester, Ralph Charles |
| author_sort | Kester, Ralph Charles |
| collection | Thesis |
| description | The existence of a stimulatory intestinal phase of gastric acid secretion has been suspected for some time, and recently the importance of this phase has been recognized. The intestinal phase is of particular interest in relation to the profound gastric hypersecretion associated with portacaval anastomosis. The results of many studies in dogs, and recently in man, have demonstrated conclusively that shunt-related gastric hyper-secretion is due to unmasking of the intestinal phase by hepatic bypass of a humoral stimulant that is normally inactivated by the liver. Definitive experiments have shown that this humoral agent is a hormone that arises in the jejunum. Elaboration of the hormone is triggered both by the entry of food into the jejunum and by a brief period of jejunal distension with a balloon. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/32033 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:33.381Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/32033 On the humoral mediation of the intestinal phase of gastric secretion Kester, Ralph Charles Gastrointestinal Hormones The existence of a stimulatory intestinal phase of gastric acid secretion has been suspected for some time, and recently the importance of this phase has been recognized. The intestinal phase is of particular interest in relation to the profound gastric hypersecretion associated with portacaval anastomosis. The results of many studies in dogs, and recently in man, have demonstrated conclusively that shunt-related gastric hyper-secretion is due to unmasking of the intestinal phase by hepatic bypass of a humoral stimulant that is normally inactivated by the liver. Definitive experiments have shown that this humoral agent is a hormone that arises in the jejunum. Elaboration of the hormone is triggered both by the entry of food into the jejunum and by a brief period of jejunal distension with a balloon. 2020-06-04T08:17:19Z 2020-06-04T08:17:19Z 1973 2020-04-07T10:31:52Z Doctoral Thesis Doctoral https://hdl.handle.net/11427/32033 eng application/pdf Department of Medicine Faculty of Health Sciences |
| spellingShingle | Gastrointestinal Hormones Kester, Ralph Charles On the humoral mediation of the intestinal phase of gastric secretion |
| thesis_degree_str | Doctoral |
| title | On the humoral mediation of the intestinal phase of gastric secretion |
| title_full | On the humoral mediation of the intestinal phase of gastric secretion |
| title_fullStr | On the humoral mediation of the intestinal phase of gastric secretion |
| title_full_unstemmed | On the humoral mediation of the intestinal phase of gastric secretion |
| title_short | On the humoral mediation of the intestinal phase of gastric secretion |
| title_sort | on the humoral mediation of the intestinal phase of gastric secretion |
| topic | Gastrointestinal Hormones |
| url | https://hdl.handle.net/11427/32033 |
| work_keys_str_mv | AT kesterralphcharles onthehumoralmediationoftheintestinalphaseofgastricsecretion |