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Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis
Includes abstract.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Human Biology
2014
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| _version_ | 1867613286731612160 |
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| access_status_str | Open Access |
| author | Uwimpuhwe, Henriette |
| author2 | Heckmann, Jeannine |
| author_browse | Heckmann, Jeannine Uwimpuhwe, Henriette |
| author_facet | Heckmann, Jeannine Uwimpuhwe, Henriette |
| author_sort | Uwimpuhwe, Henriette |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3208 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:43.673Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Human Biology |
| publisherStr | Department of Human Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3208 Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis Uwimpuhwe, Henriette Heckmann, Jeannine Ballo, Robea Prince, Sharon Medicine Includes abstract. Includes bibliographical references (leaves 73-83). Myasthenia gravis (MG) is an autoimmune disorder in which auto-antibodies directed at the acetylcholine receptors (AChR) of the neuromuscular junction (NMJ) block, alter or destroy their targets. The anti-AChR antibodies cause activation of the classical complement pathway leading to inflammatory injury at the NMJ. Decay Accelerating Factor (DAF), a member of complement regulatory proteins, prevents activation of autologous components of complement pathways. The absence of DAF, in knock-out mouse models, has been shown to significantly increase the susceptibility to experimental autoimmune MG. A previous study showed that a high proportion of South African MG patients of African genetic ancestry develop immunosuppressive therapyresistant extraocular muscle (EOM) dysfunction. We hypothesized that these patients have deficient DAF expression in their EOMs resulting in less protection from complement injury. 2014-07-28T18:15:37Z 2014-07-28T18:15:37Z 2009 Master Thesis Masters MSc http://hdl.handle.net/11427/3208 eng application/pdf Department of Human Biology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Uwimpuhwe, Henriette Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis |
| thesis_degree_str | Master's |
| title | Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis |
| title_full | Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis |
| title_fullStr | Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis |
| title_full_unstemmed | Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis |
| title_short | Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis |
| title_sort | molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in myasthenia gravis |
| topic | Medicine |
| url | http://hdl.handle.net/11427/3208 |
| work_keys_str_mv | AT uwimpuhwehenriette molecularanalysisofdecayacceleratingfactorasapotentialsusceptibilityfactortodevelopingtreatmentresistantextraocularmuscleinvolvementinmyastheniagravis |