Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum
Includes bibliographical references (leaves 94-103).
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Clinical Pharmacology
2014
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613165580189696 |
|---|---|
| access_status_str | Open Access |
| author | Smythe, Wynand Anton |
| author2 | Hoppe, Heinrich C |
| author_browse | Hoppe, Heinrich C Smythe, Wynand Anton |
| author_facet | Hoppe, Heinrich C Smythe, Wynand Anton |
| author_sort | Smythe, Wynand Anton |
| collection | Thesis |
| description | Includes bibliographical references (leaves 94-103). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3301 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:48.735Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Clinical Pharmacology |
| publisherStr | Division of Clinical Pharmacology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3301 Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum Smythe, Wynand Anton Hoppe, Heinrich C Pharmacology Includes bibliographical references (leaves 94-103). By contrast to mammalian cells, very little is known about endocytosis in the malaria parasite. However, endocytosis via the cytostome is required by the parasite to ingest haemoglobin from its host cytosol which it transports within double membrane vesicles to the digestive vacuole, where digestion occurs and metabolites are used mostly for nutritional purposes. To gain a deeper understanding of the molecular basis and mechanisms of this vital process, a panel of inhibitors was used to inhibit the actin cytoskeleton and PI (3) kinases in the parasite. In this study Cytochalasin D and Latrunculin A, which depolymerise and prevent actin fimalment formation, Jasplakinolide, which stabilises actin filaments, and Wormannin and LY294002, which inhibit PI 93) kinase, were used to study actin disrupting and PI (3) kinase inhibiting drug effects on haemoglobin endocytosis and transport vesicle trafficking within the malaria parasite Plasmodium falciparum. 2014-07-28T18:20:52Z 2014-07-28T18:20:52Z 2007 Master Thesis Masters MSc http://hdl.handle.net/11427/3301 eng application/pdf Division of Clinical Pharmacology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Pharmacology Smythe, Wynand Anton Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum |
| thesis_degree_str | Master's |
| title | Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum |
| title_full | Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum |
| title_fullStr | Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum |
| title_full_unstemmed | Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum |
| title_short | Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum |
| title_sort | characterising the role of actin and pi 3 kinases in endocytosis in the malaria parasite plasmodium falciparum |
| topic | Pharmacology |
| url | http://hdl.handle.net/11427/3301 |
| work_keys_str_mv | AT smythewynandanton characterisingtheroleofactinandpi3kinasesinendocytosisinthemalariaparasiteplasmodiumfalciparum |