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Dysbetalipoproteinaemia : clinical and laboratory aspects, changes in lipoprotein composition and remnant metabolism associated with lipid lowering drugs
Includes bibliographical references (p. 483-539).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Medicine
2014
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| _version_ | 1867614281495740416 |
|---|---|
| access_status_str | Open Access |
| author | Blom, Dirk Jacobus |
| author2 | Marais, A David |
| author_browse | Blom, Dirk Jacobus Marais, A David |
| author_facet | Marais, A David Blom, Dirk Jacobus |
| author_sort | Blom, Dirk Jacobus |
| collection | Thesis |
| description | Includes bibliographical references (p. 483-539). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3364 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:49:33.216Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3364 Dysbetalipoproteinaemia : clinical and laboratory aspects, changes in lipoprotein composition and remnant metabolism associated with lipid lowering drugs Blom, Dirk Jacobus Marais, A David Medicine Includes bibliographical references (p. 483-539). This thesis examines and reviews multiple aspects of dysbetalipoproteinaemia. Dysbetalipoproteinaemia is a severe, highly atherogenic mixed hyperlipidaernia characterized by the accumulation of remnants of triglyceride-rich lipoproteins. Genetic susceptibility is conferred by mutations in apolipoproteinE, but manifest hyperlipidaemia often only occurs in the presence of metabolic abnormalities that influence lipoprotein production or clearance. Normal lipid metabolism is briefly reviewed to enable a better understanding of the pathophysiology of dysbetalipoproteinaernia. Hepatic remnant clearance is reviewed in detail with particular emphasis on the roles of all hepatic lipoprotein receptors. The importance of differential hepatic lipoprotein receptor binding affinities according to apoE mutation is emphasized. 2014-07-29T09:02:44Z 2014-07-29T09:02:44Z 2007 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3364 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Blom, Dirk Jacobus Dysbetalipoproteinaemia : clinical and laboratory aspects, changes in lipoprotein composition and remnant metabolism associated with lipid lowering drugs |
| thesis_degree_str | Doctoral |
| title | Dysbetalipoproteinaemia : clinical and laboratory aspects, changes in lipoprotein composition and remnant metabolism associated with lipid lowering drugs |
| title_full | Dysbetalipoproteinaemia : clinical and laboratory aspects, changes in lipoprotein composition and remnant metabolism associated with lipid lowering drugs |
| title_fullStr | Dysbetalipoproteinaemia : clinical and laboratory aspects, changes in lipoprotein composition and remnant metabolism associated with lipid lowering drugs |
| title_full_unstemmed | Dysbetalipoproteinaemia : clinical and laboratory aspects, changes in lipoprotein composition and remnant metabolism associated with lipid lowering drugs |
| title_short | Dysbetalipoproteinaemia : clinical and laboratory aspects, changes in lipoprotein composition and remnant metabolism associated with lipid lowering drugs |
| title_sort | dysbetalipoproteinaemia clinical and laboratory aspects changes in lipoprotein composition and remnant metabolism associated with lipid lowering drugs |
| topic | Medicine |
| url | http://hdl.handle.net/11427/3364 |
| work_keys_str_mv | AT blomdirkjacobus dysbetalipoproteinaemiaclinicalandlaboratoryaspectschangesinlipoproteincompositionandremnantmetabolismassociatedwithlipidloweringdrugs |