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The development of aptamer-based probes for the detection of TB antigens ESAT-6.CFP-10 potential TB diagnostic tools
Includes abstract.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Medicine
2014
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| _version_ | 1867613290684743680 |
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| access_status_str | Open Access |
| author | Maserumule, Matsopiane Charlotte |
| author2 | Dheda, Keertan |
| author_browse | Dheda, Keertan Maserumule, Matsopiane Charlotte |
| author_facet | Dheda, Keertan Maserumule, Matsopiane Charlotte |
| author_sort | Maserumule, Matsopiane Charlotte |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3425 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:48.261Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3425 The development of aptamer-based probes for the detection of TB antigens ESAT-6.CFP-10 potential TB diagnostic tools Maserumule, Matsopiane Charlotte Dheda, Keertan Khati, Makobetsa Gresh, Lionel Medicine Includes abstract. Includes bibliographical references. Lack of point-of-care (PoC) diagnostic tools for TB hinders control of the disease, particularly in resource-limited, high HIV and TB prevalence countries. Therefore, there is a need for simple, rapid, accurate, and affordable PoC diagnostics to detect active TB early enough for opportune intervention. To develop TB detection probes that will constitute such diagnostics, our research group recently isolated DNA aptamers that bind to a putative marker for active TB; the ESAT-6.CFP-10 heterodimer. Aptamers are highly specific artificial mimics of antibodies that have shown great prospects in diagnostic applications. The aim of this study was to characterise the anti-ESAT-6.CFP-10 aptamers, and to optimise them into more specific and affordable detection probes for the development of potential PoC TB diagnostic tools. 2014-07-29T09:07:14Z 2014-07-29T09:07:14Z 2013 Master Thesis Masters MSc http://hdl.handle.net/11427/3425 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Maserumule, Matsopiane Charlotte The development of aptamer-based probes for the detection of TB antigens ESAT-6.CFP-10 potential TB diagnostic tools |
| thesis_degree_str | Master's |
| title | The development of aptamer-based probes for the detection of TB antigens ESAT-6.CFP-10 potential TB diagnostic tools |
| title_full | The development of aptamer-based probes for the detection of TB antigens ESAT-6.CFP-10 potential TB diagnostic tools |
| title_fullStr | The development of aptamer-based probes for the detection of TB antigens ESAT-6.CFP-10 potential TB diagnostic tools |
| title_full_unstemmed | The development of aptamer-based probes for the detection of TB antigens ESAT-6.CFP-10 potential TB diagnostic tools |
| title_short | The development of aptamer-based probes for the detection of TB antigens ESAT-6.CFP-10 potential TB diagnostic tools |
| title_sort | development of aptamer based probes for the detection of tb antigens esat 6 cfp 10 potential tb diagnostic tools |
| topic | Medicine |
| url | http://hdl.handle.net/11427/3425 |
| work_keys_str_mv | AT maserumulematsopianecharlotte thedevelopmentofaptamerbasedprobesforthedetectionoftbantigensesat6cfp10potentialtbdiagnostictools AT maserumulematsopianecharlotte developmentofaptamerbasedprobesforthedetectionoftbantigensesat6cfp10potentialtbdiagnostictools |