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PKCε and cardioprotection : an exploration of putative mechanisms
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Medicine
2014
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| _version_ | 1867613215674859520 |
|---|---|
| access_status_str | Open Access |
| author | McCarthy, Joy |
| author2 | Essop, Faadiel |
| author_browse | Essop, Faadiel McCarthy, Joy |
| author_facet | Essop, Faadiel McCarthy, Joy |
| author_sort | McCarthy, Joy |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3429 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:36.207Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3429 PKCε and cardioprotection : an exploration of putative mechanisms McCarthy, Joy Essop, Faadiel Opie, Lionel H Medicine Includes bibliographical references. Recent studies have investigated the underlying regulatory mechanisms that may explain the cardioprotective role of PKCε. Sub-proteome analysis has identified interactions between activated PKCε and various mitochondrial proteins, which orchestrate mitochondrial homeostasis, including proteins governing mitochondrial oxidative phosphorylation, electron transfer, ion transport and control of mitochondrial permeability transition (MPT). MPT disruption is regarded as a key step in the initiation of an apoptotic cascade. However, brief pore opening may be beneficial in triggering the generation of small amounts of protective reactive oxygen species (ROS) and restoring calcium homeostasis. PKCε also interacts with adenine nucleotide translocases (ANTs), inner mitochondrial membrane proteins essential for ATP production and an integral component of the permeability transition pore. An augmented capacity to generate ATP would fundamentally enhance resilience to ischemia. 2014-07-29T09:07:21Z 2014-07-29T09:07:21Z 2006 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3429 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine McCarthy, Joy PKCε and cardioprotection : an exploration of putative mechanisms |
| thesis_degree_str | Doctoral |
| title | PKCε and cardioprotection : an exploration of putative mechanisms |
| title_full | PKCε and cardioprotection : an exploration of putative mechanisms |
| title_fullStr | PKCε and cardioprotection : an exploration of putative mechanisms |
| title_full_unstemmed | PKCε and cardioprotection : an exploration of putative mechanisms |
| title_short | PKCε and cardioprotection : an exploration of putative mechanisms |
| title_sort | pkcε and cardioprotection an exploration of putative mechanisms |
| topic | Medicine |
| url | http://hdl.handle.net/11427/3429 |
| work_keys_str_mv | AT mccarthyjoy pkceandcardioprotectionanexplorationofputativemechanisms |