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Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species
Bibliography: leaves 163-203.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Medicine
2014
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| _version_ | 1867613384474624000 |
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| access_status_str | Open Access |
| author | Siziba, Kwanele Bennett |
| author2 | Meissner, Peter |
| author_browse | Meissner, Peter Siziba, Kwanele Bennett |
| author_facet | Meissner, Peter Siziba, Kwanele Bennett |
| author_sort | Siziba, Kwanele Bennett |
| collection | Thesis |
| description | Bibliography: leaves 163-203. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3464 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:35:17.749Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3464 Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species Siziba, Kwanele Bennett Meissner, Peter Corrigall, Anne Medicine Bibliography: leaves 163-203. This work involved the characterisation of protoporphyrinogen oxidase (PPO), the penultimate enzyme in haem biosynthesis, from Bacillus subtilis, Myxococcus xanthus, and human. A defect in human PPO causes variegate porphyria, an autosomal dominant disorder characterised by skin photosensitivity and propensity towards acute neurovisceral crises. At the beginning of this project little information was available on the kinetic and biophysical properties of isolated PPOs due largely to difficulties associated with their purification from natural sources. 2014-07-29T09:10:30Z 2014-07-29T09:10:30Z 2000 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3464 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Siziba, Kwanele Bennett Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species |
| thesis_degree_str | Doctoral |
| title | Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species |
| title_full | Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species |
| title_fullStr | Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species |
| title_full_unstemmed | Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species |
| title_short | Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species |
| title_sort | expression purification and characterisation of protoporphyrinogen oxidases from diverse species |
| topic | Medicine |
| url | http://hdl.handle.net/11427/3464 |
| work_keys_str_mv | AT sizibakwanelebennett expressionpurificationandcharacterisationofprotoporphyrinogenoxidasesfromdiversespecies |