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Does hair curl variation influence the efficacy of scalp cooling in the prevention of chemotherapy-induced alopecia in breast cancer patients? A randomized controlled pilot study
Background: Chemotherapy-induced alopecia (CIA) is a common side-effect of breast cancer treatment. Scalp cooling is reported to reduce CIA; however, it is unknown whether the efficacy is influenced by hair curvature. Methods: This 20-month randomized controlled trial recruited females, (18-65 years...
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| Format: | Thesis |
| Language: | English |
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Division of Radiology
2022
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| _version_ | 1867613190243745793 |
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| access_status_str | Open Access |
| author | Obuseng, Odirile |
| author2 | Khumalo, Nonhlanhla P |
| author_browse | Khumalo, Nonhlanhla P Obuseng, Odirile |
| author_facet | Khumalo, Nonhlanhla P Obuseng, Odirile |
| author_sort | Obuseng, Odirile |
| collection | Thesis |
| description | Background: Chemotherapy-induced alopecia (CIA) is a common side-effect of breast cancer treatment. Scalp cooling is reported to reduce CIA; however, it is unknown whether the efficacy is influenced by hair curvature. Methods: This 20-month randomized controlled trial recruited females, (18-65 years) with breast cancer to receive chemotherapy (Adriamycin or Epirubicin and Cyclophosphamide followed by Paclitaxel) with or without scalp cooling. The main outcomes were percentage alopecia (Severity ALopecia Tool scored by 3 dermatologists) in straight versus curly hair and treatment retention rates. Results: Forty-eight patients (24 per group) were randomized; 4 in each group withdrew before study visit1 and photographs of 3 in the cooling group could not be found for severity assessment. Thus 77% constituted the intention to treat population (17 cooling versus 20 control). Agreement on alopecia severity was good overall (ICC=0,94; 95% CI: 0.85 - 0.97) and at 6 of 7 time points. Overall, cooling significantly reduced CIA, relative to no cooling (58.15 ± 28.46 versus 37.29 ± 20.52; p:0.0167), however, percentage alopecia was cosmetically significant. There was no difference in CIA between cooling participants with straight (8) versus curly hair (9), (p:0.0740). The number of patients completing the various cycles of chemotherapy, declined from 77.1% at cycle 1 to 18.8% at cycle 7 for the whole study; from 100% each to 17.6% and 30% for cooling and control groups, respectively (p:0.451). Conclusions: This small study suggests that hair curvature has no significant impact on the efficacy of scalp cooling to reduce CIA, however this requires confirmation. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/35515 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:12.136Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Division of Radiology |
| publisherStr | Division of Radiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/35515 Does hair curl variation influence the efficacy of scalp cooling in the prevention of chemotherapy-induced alopecia in breast cancer patients? A randomized controlled pilot study Obuseng, Odirile Khumalo, Nonhlanhla P Naiker, Thurandrie Thebe, Tselane radiology Background: Chemotherapy-induced alopecia (CIA) is a common side-effect of breast cancer treatment. Scalp cooling is reported to reduce CIA; however, it is unknown whether the efficacy is influenced by hair curvature. Methods: This 20-month randomized controlled trial recruited females, (18-65 years) with breast cancer to receive chemotherapy (Adriamycin or Epirubicin and Cyclophosphamide followed by Paclitaxel) with or without scalp cooling. The main outcomes were percentage alopecia (Severity ALopecia Tool scored by 3 dermatologists) in straight versus curly hair and treatment retention rates. Results: Forty-eight patients (24 per group) were randomized; 4 in each group withdrew before study visit1 and photographs of 3 in the cooling group could not be found for severity assessment. Thus 77% constituted the intention to treat population (17 cooling versus 20 control). Agreement on alopecia severity was good overall (ICC=0,94; 95% CI: 0.85 - 0.97) and at 6 of 7 time points. Overall, cooling significantly reduced CIA, relative to no cooling (58.15 ± 28.46 versus 37.29 ± 20.52; p:0.0167), however, percentage alopecia was cosmetically significant. There was no difference in CIA between cooling participants with straight (8) versus curly hair (9), (p:0.0740). The number of patients completing the various cycles of chemotherapy, declined from 77.1% at cycle 1 to 18.8% at cycle 7 for the whole study; from 100% each to 17.6% and 30% for cooling and control groups, respectively (p:0.451). Conclusions: This small study suggests that hair curvature has no significant impact on the efficacy of scalp cooling to reduce CIA, however this requires confirmation. 2022-01-18T10:10:14Z 2022-01-18T10:10:14Z 2021 2022-01-18T10:09:31Z Master Thesis Masters MMed http://hdl.handle.net/11427/35515 eng application/pdf Division of Radiology Faculty of Health Sciences |
| spellingShingle | radiology Obuseng, Odirile Does hair curl variation influence the efficacy of scalp cooling in the prevention of chemotherapy-induced alopecia in breast cancer patients? A randomized controlled pilot study |
| thesis_degree_str | Master's |
| title | Does hair curl variation influence the efficacy of scalp cooling in the prevention of chemotherapy-induced alopecia in breast cancer patients? A randomized controlled pilot study |
| title_full | Does hair curl variation influence the efficacy of scalp cooling in the prevention of chemotherapy-induced alopecia in breast cancer patients? A randomized controlled pilot study |
| title_fullStr | Does hair curl variation influence the efficacy of scalp cooling in the prevention of chemotherapy-induced alopecia in breast cancer patients? A randomized controlled pilot study |
| title_full_unstemmed | Does hair curl variation influence the efficacy of scalp cooling in the prevention of chemotherapy-induced alopecia in breast cancer patients? A randomized controlled pilot study |
| title_short | Does hair curl variation influence the efficacy of scalp cooling in the prevention of chemotherapy-induced alopecia in breast cancer patients? A randomized controlled pilot study |
| title_sort | does hair curl variation influence the efficacy of scalp cooling in the prevention of chemotherapy induced alopecia in breast cancer patients a randomized controlled pilot study |
| topic | radiology |
| url | http://hdl.handle.net/11427/35515 |
| work_keys_str_mv | AT obusengodirile doeshaircurlvariationinfluencetheefficacyofscalpcoolinginthepreventionofchemotherapyinducedalopeciainbreastcancerpatientsarandomizedcontrolledpilotstudy |