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Screening strategies for adults with type 2 diabetes mellitus
There are insufficient randomized controlled trials to address whether screening for type 2 diabetes mellitus (T2DM) improves health outcomes. This systematic review sought to cast a wider net and synthesise evidence from non-randomised intervention studies to assess the effectiveness of T2DM screen...
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| Format: | Thesis |
| Language: | English |
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Department of Public Health and Family Medicine
2022
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| _version_ | 1867613226122870784 |
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| access_status_str | Open Access |
| author | Mearns, Helen |
| author2 | Kagina, Benjamin M |
| author_browse | Kagina, Benjamin M Mearns, Helen |
| author_facet | Kagina, Benjamin M Mearns, Helen |
| author_sort | Mearns, Helen |
| collection | Thesis |
| description | There are insufficient randomized controlled trials to address whether screening for type 2 diabetes mellitus (T2DM) improves health outcomes. This systematic review sought to cast a wider net and synthesise evidence from non-randomised intervention studies to assess the effectiveness of T2DM screening in adults for reducing mortality and T2DM-associated morbidity. We searched PubMed/MEDLINE, Scopus, Web of Science, CINAHL, Academic Search Premier and Health Source Nursing Academic (inception onwards; last search July 2021). We included non-randomised intervention studies that assessed T2DM screening compared to no screening, in adults without known T2DM. Screening was performed independently by two reviewers. Data was abstracted by one reviewer and checked by a second, as was risk of bias (ROBINS-I) and certainty of evidence (GRADE). A narrative summary was performed. We screened 10,892 records, retrieving 67 for full-text screening with one record meeting inclusion criteria. The study was a prospective cohort comparing T2DM screening versus no screening. It included adults, 40 - 65 years, with no known T2DM from a single community practice in Ely, England (N = 4,936) and evaluated outcomes at two time periods. The study was assessed as having moderate risk of bias. There may be little or no difference in mortality between those who were invited to screening versus those who were not invited (1990-1999: adjusted hazard ratio (aHR) 0.79 [95% confidence interval (CI) 0.63 – 1.00], n = 4,936, low certainty evidence and 2000 - 2008: aHR 1.18 [95% CI 0.93 - 1.51], n = 3,002, low certainty evidence). We found only one study reporting the effectiveness of screening for T2DM in adults. Therefore, despite ongoing T2DM screening in clinical care, this review highlights an important research gap in understanding the true health benefits of screening. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/36489 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:46.693Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Department of Public Health and Family Medicine |
| publisherStr | Department of Public Health and Family Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/36489 Screening strategies for adults with type 2 diabetes mellitus Mearns, Helen Kagina, Benjamin M Kredo, Tamara Schmidt, Bey-Marrié public health family medicine There are insufficient randomized controlled trials to address whether screening for type 2 diabetes mellitus (T2DM) improves health outcomes. This systematic review sought to cast a wider net and synthesise evidence from non-randomised intervention studies to assess the effectiveness of T2DM screening in adults for reducing mortality and T2DM-associated morbidity. We searched PubMed/MEDLINE, Scopus, Web of Science, CINAHL, Academic Search Premier and Health Source Nursing Academic (inception onwards; last search July 2021). We included non-randomised intervention studies that assessed T2DM screening compared to no screening, in adults without known T2DM. Screening was performed independently by two reviewers. Data was abstracted by one reviewer and checked by a second, as was risk of bias (ROBINS-I) and certainty of evidence (GRADE). A narrative summary was performed. We screened 10,892 records, retrieving 67 for full-text screening with one record meeting inclusion criteria. The study was a prospective cohort comparing T2DM screening versus no screening. It included adults, 40 - 65 years, with no known T2DM from a single community practice in Ely, England (N = 4,936) and evaluated outcomes at two time periods. The study was assessed as having moderate risk of bias. There may be little or no difference in mortality between those who were invited to screening versus those who were not invited (1990-1999: adjusted hazard ratio (aHR) 0.79 [95% confidence interval (CI) 0.63 – 1.00], n = 4,936, low certainty evidence and 2000 - 2008: aHR 1.18 [95% CI 0.93 - 1.51], n = 3,002, low certainty evidence). We found only one study reporting the effectiveness of screening for T2DM in adults. Therefore, despite ongoing T2DM screening in clinical care, this review highlights an important research gap in understanding the true health benefits of screening. 2022-06-21T10:48:00Z 2022-06-21T10:48:00Z 2022 2022-06-21T10:47:33Z Master Thesis Masters MPH http://hdl.handle.net/11427/36489 eng application/pdf Department of Public Health and Family Medicine Faculty of Health Sciences |
| spellingShingle | public health family medicine Mearns, Helen Screening strategies for adults with type 2 diabetes mellitus |
| thesis_degree_str | Master's |
| title | Screening strategies for adults with type 2 diabetes mellitus |
| title_full | Screening strategies for adults with type 2 diabetes mellitus |
| title_fullStr | Screening strategies for adults with type 2 diabetes mellitus |
| title_full_unstemmed | Screening strategies for adults with type 2 diabetes mellitus |
| title_short | Screening strategies for adults with type 2 diabetes mellitus |
| title_sort | screening strategies for adults with type 2 diabetes mellitus |
| topic | public health family medicine |
| url | http://hdl.handle.net/11427/36489 |
| work_keys_str_mv | AT mearnshelen screeningstrategiesforadultswithtype2diabetesmellitus |