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Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital
Background. Group B Streptococcal disease is an important cause of morbidity and mortality in newborns globally, and is more common in Sub-Saharan Africa and South Africa. There are few studies reporting on the burden of invasive Group B Streptococcus disease (iGBS) in newborns in South Africa, espe...
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| Format: | Thesis |
| Language: | English |
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Department of Paediatrics and Child Health
2024
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| _version_ | 1867613280703348736 |
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| access_status_str | Open Access |
| author | Browne, Bradley |
| author2 | Tooke, Lloyd |
| author_browse | Browne, Bradley Tooke, Lloyd |
| author_facet | Tooke, Lloyd Browne, Bradley |
| author_sort | Browne, Bradley |
| collection | Thesis |
| description | Background. Group B Streptococcal disease is an important cause of morbidity and mortality in newborns globally, and is more common in Sub-Saharan Africa and South Africa. There are few studies reporting on the burden of invasive Group B Streptococcus disease (iGBS) in newborns in South Africa, especially in the Western Cape. Objective. This study aims to describe a case series of newborns with iGBS in a tertiary hospital in the Western Cape. Methods. A retrospective folder review was conducted between January 2015 and December 2020. Results. Thirty five cases of invasive GBS disease were included in the study, 51% with earlyonset disease (EoD) and 49% with late-onset disease (LoD). The median gestational age at birth was 27 and 31.5 weeks in the LoD and EoD groups respectively. The median birth weight was 900 g and 1812 g in the LoD and EoD group respectively. Meningits was more common in the LoD group, and pneumonia more common in the EoD group. The overall mortality rate was 23%, and GBS disease accounted for a cumulative 274 days in the intensive care unit. Conclusion. Invasive GBS disease in newborns at GSH carries a high mortality rate with a similar burden of LoD and EoD. More studies of newborn iGBS are needed in the Western Cape and South Africa to better understand the burden of disease. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/39301 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:37.862Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Department of Paediatrics and Child Health |
| publisherStr | Department of Paediatrics and Child Health |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/39301 Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital Browne, Bradley Tooke, Lloyd Paediatrics Background. Group B Streptococcal disease is an important cause of morbidity and mortality in newborns globally, and is more common in Sub-Saharan Africa and South Africa. There are few studies reporting on the burden of invasive Group B Streptococcus disease (iGBS) in newborns in South Africa, especially in the Western Cape. Objective. This study aims to describe a case series of newborns with iGBS in a tertiary hospital in the Western Cape. Methods. A retrospective folder review was conducted between January 2015 and December 2020. Results. Thirty five cases of invasive GBS disease were included in the study, 51% with earlyonset disease (EoD) and 49% with late-onset disease (LoD). The median gestational age at birth was 27 and 31.5 weeks in the LoD and EoD groups respectively. The median birth weight was 900 g and 1812 g in the LoD and EoD group respectively. Meningits was more common in the LoD group, and pneumonia more common in the EoD group. The overall mortality rate was 23%, and GBS disease accounted for a cumulative 274 days in the intensive care unit. Conclusion. Invasive GBS disease in newborns at GSH carries a high mortality rate with a similar burden of LoD and EoD. More studies of newborn iGBS are needed in the Western Cape and South Africa to better understand the burden of disease. 2024-04-04T08:15:03Z 2024-04-04T08:15:03Z 2023 2024-04-04T06:48:57Z Thesis / Dissertation Masters MMed http://hdl.handle.net/11427/39301 eng application/pdf Department of Paediatrics and Child Health Faculty of Health Sciences |
| spellingShingle | Paediatrics Browne, Bradley Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital |
| thesis_degree_str | Master's |
| title | Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital |
| title_full | Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital |
| title_fullStr | Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital |
| title_full_unstemmed | Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital |
| title_short | Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital |
| title_sort | invasive group b streptococcal disease in newborns at groote schuur hospital |
| topic | Paediatrics |
| url | http://hdl.handle.net/11427/39301 |
| work_keys_str_mv | AT brownebradley invasivegroupbstreptococcaldiseaseinnewbornsatgrooteschuurhospital |