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Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa
Background: Nutrition in chronic liver disease is an important marker of post- liver transplant outcomes in children and is monitored judiciously pre-transplantation. There is a paucity of data on post-transplant nutritional outcomes, particularly in the developing world setting. Aim: To describe th...
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| Format: | Thesis |
| Language: | English |
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Department of Paediatrics and Child Health
2024
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| _version_ | 1867613308242100224 |
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| access_status_str | Open Access |
| author | Ndhlovu, Lesego |
| author2 | de Lacy, Ronalda |
| author_browse | Ndhlovu, Lesego de Lacy, Ronalda |
| author_facet | de Lacy, Ronalda Ndhlovu, Lesego |
| author_sort | Ndhlovu, Lesego |
| collection | Thesis |
| description | Background: Nutrition in chronic liver disease is an important marker of post- liver transplant outcomes in children and is monitored judiciously pre-transplantation. There is a paucity of data on post-transplant nutritional outcomes, particularly in the developing world setting. Aim: To describe the nutritional outcomes of children following liver transplantation. Methods: A retrospective study of patient's receiving post-transplant care at Red Cross War Memorial Children's Hospital in Cape Town, South Africa from 2004 – 2019. Results: 31 children were included in the analysis. Pre-transplant prevalence of stunting was 57,1%, with 32,1% of children severely stunted. At 24 months post-transplant 65,5% of children were stunted, with 44,8% severely stunted. Overweight and obesity prevalence was 0% pretransplant, and 32,2% and 27,6% at 12- and 24-months post-transplant respectively. Biliary atresia was the diagnosis in 89,5% of children with stunting at 24 months vs in 50% of children without stunting at 24 months post-transplant (p = 0.03). Mean pre-transplant albumin was lower in children with stunting at 24 months post-transplant than in children without stunting (26,7 vs 29,6 g/L respectively; p < 0,001). Age at transplant was lower in children with stunting at 24 months post-transplant vs children without stunting (40,7 versus 91,5 months; p < 0.001). Twenty-one (67,7%) children developed hypertension post-transplant. Conclusion: Stunting, hypertension and overweight/obesity are highly prevalent post paediatric liver transplantation. Lower pre-transplant albumin, younger age at transplant, and diagnosis of biliary atresia were associated with post-transplant stunting. Post-transplant growth monitoring seems prudent to prevent the development of overnutrition and associated metabolic complications. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/39758 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:03.682Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Department of Paediatrics and Child Health |
| publisherStr | Department of Paediatrics and Child Health |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/39758 Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa Ndhlovu, Lesego de Lacy, Ronalda Paediatric Gastroenterology Background: Nutrition in chronic liver disease is an important marker of post- liver transplant outcomes in children and is monitored judiciously pre-transplantation. There is a paucity of data on post-transplant nutritional outcomes, particularly in the developing world setting. Aim: To describe the nutritional outcomes of children following liver transplantation. Methods: A retrospective study of patient's receiving post-transplant care at Red Cross War Memorial Children's Hospital in Cape Town, South Africa from 2004 – 2019. Results: 31 children were included in the analysis. Pre-transplant prevalence of stunting was 57,1%, with 32,1% of children severely stunted. At 24 months post-transplant 65,5% of children were stunted, with 44,8% severely stunted. Overweight and obesity prevalence was 0% pretransplant, and 32,2% and 27,6% at 12- and 24-months post-transplant respectively. Biliary atresia was the diagnosis in 89,5% of children with stunting at 24 months vs in 50% of children without stunting at 24 months post-transplant (p = 0.03). Mean pre-transplant albumin was lower in children with stunting at 24 months post-transplant than in children without stunting (26,7 vs 29,6 g/L respectively; p < 0,001). Age at transplant was lower in children with stunting at 24 months post-transplant vs children without stunting (40,7 versus 91,5 months; p < 0.001). Twenty-one (67,7%) children developed hypertension post-transplant. Conclusion: Stunting, hypertension and overweight/obesity are highly prevalent post paediatric liver transplantation. Lower pre-transplant albumin, younger age at transplant, and diagnosis of biliary atresia were associated with post-transplant stunting. Post-transplant growth monitoring seems prudent to prevent the development of overnutrition and associated metabolic complications. 2024-05-30T09:41:07Z 2024-05-30T09:41:07Z 2023 2024-05-28T08:39:29Z Thesis / Dissertation Masters MPhil http://hdl.handle.net/11427/39758 eng application/pdf Department of Paediatrics and Child Health Faculty of Health Sciences |
| spellingShingle | Paediatric Gastroenterology Ndhlovu, Lesego Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa |
| thesis_degree_str | Master's |
| title | Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa |
| title_full | Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa |
| title_fullStr | Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa |
| title_full_unstemmed | Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa |
| title_short | Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa |
| title_sort | describing the nutritional outcomes following paediatric liver transplantation at a tertiary hospital in south africa |
| topic | Paediatric Gastroenterology |
| url | http://hdl.handle.net/11427/39758 |
| work_keys_str_mv | AT ndhlovulesego describingthenutritionaloutcomesfollowingpaediatriclivertransplantationatatertiaryhospitalinsouthafrica |