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Examining personal memory in film: A reflection of documenting memory-stories in Reimagining Memories
Background Treatment-limiting severe cutaneous adverse reactions (SCAR) occur more commonly amongst persons co-infected with tuberculosis (TB) and advanced HIV. The impact of SCAR on long-term HIV and TB outcomes is unknown. Methods Patients with active TB and/or HIV admitted to Groote Schuur Hospit...
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| Format: | Thesis |
| Language: | English |
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Centre for Film and Media Studies
2024
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| _version_ | 1867613168142909440 |
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| access_status_str | Open Access |
| author | Mathafeng, Refiloe |
| author2 | Modisane, Litheko |
| author_browse | Mathafeng, Refiloe Modisane, Litheko |
| author_facet | Modisane, Litheko Mathafeng, Refiloe |
| author_sort | Mathafeng, Refiloe |
| collection | Thesis |
| description | Background Treatment-limiting severe cutaneous adverse reactions (SCAR) occur more commonly amongst persons co-infected with tuberculosis (TB) and advanced HIV. The impact of SCAR on long-term HIV and TB outcomes is unknown. Methods Patients with active TB and/or HIV admitted to Groote Schuur Hospital, Cape Town, South Africa with SCAR between 1/10/2018 and 30/09/2021 were eligible. Clinical and laboratory follow-up data was collected for 6 and 12-month outcomes: mortality, TB and antiretroviral therapy (ART) regimen changes, TB treatment completion, and CD4 count recovery. Results Forty-eight SCAR admissions included: 34, 11, and 3 HIV-associated TB, HIV-only and TB-only patients with 32, 13 and 3 cases of drug reaction with eosinophilia and systemic symptoms, StevensJohnson syndrome/toxic epidermal necrolysis and generalised bullous fixed drug eruption respectively. Nine (19%), all HIV-positive, were deceased at 12-months, and 12 (25%) were lost to all care levels. Amongst TB-SCAR patients, seven (21%) were discharged on all four first-line anti-TB drugs (FLTD), while 12 (33%) had discharge regimens with no FLTDs; 24/37 (65%) completed TB treatment. Amongst HIV-SCAR patients, 10/31 (32%) changed ART regimen. If retained in care (24/36), median (IQR) CD4 counts increased by 12-months post-SCAR (115 (62-175) vs. 319 (134-439) cells/uL). Conclusion SCAR admission amongst patients with HIV-associated TB results in substantial mortality, and considerable treatment complexity. However, if retained in care, TB regimens are successfully completed, and immune recovery is good despite SCAR. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/39914 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:50.330Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Centre for Film and Media Studies |
| publisherStr | Centre for Film and Media Studies |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/39914 Examining personal memory in film: A reflection of documenting memory-stories in Reimagining Memories Mathafeng, Refiloe Modisane, Litheko Documentary Arts Background Treatment-limiting severe cutaneous adverse reactions (SCAR) occur more commonly amongst persons co-infected with tuberculosis (TB) and advanced HIV. The impact of SCAR on long-term HIV and TB outcomes is unknown. Methods Patients with active TB and/or HIV admitted to Groote Schuur Hospital, Cape Town, South Africa with SCAR between 1/10/2018 and 30/09/2021 were eligible. Clinical and laboratory follow-up data was collected for 6 and 12-month outcomes: mortality, TB and antiretroviral therapy (ART) regimen changes, TB treatment completion, and CD4 count recovery. Results Forty-eight SCAR admissions included: 34, 11, and 3 HIV-associated TB, HIV-only and TB-only patients with 32, 13 and 3 cases of drug reaction with eosinophilia and systemic symptoms, StevensJohnson syndrome/toxic epidermal necrolysis and generalised bullous fixed drug eruption respectively. Nine (19%), all HIV-positive, were deceased at 12-months, and 12 (25%) were lost to all care levels. Amongst TB-SCAR patients, seven (21%) were discharged on all four first-line anti-TB drugs (FLTD), while 12 (33%) had discharge regimens with no FLTDs; 24/37 (65%) completed TB treatment. Amongst HIV-SCAR patients, 10/31 (32%) changed ART regimen. If retained in care (24/36), median (IQR) CD4 counts increased by 12-months post-SCAR (115 (62-175) vs. 319 (134-439) cells/uL). Conclusion SCAR admission amongst patients with HIV-associated TB results in substantial mortality, and considerable treatment complexity. However, if retained in care, TB regimens are successfully completed, and immune recovery is good despite SCAR. 2024-06-19T07:20:15Z 2024-06-19T07:20:15Z 2023 2024-06-06T13:56:07Z Thesis / Dissertation Masters MA http://hdl.handle.net/11427/39914 eng application/pdf Centre for Film and Media Studies Faculty of Humanities |
| spellingShingle | Documentary Arts Mathafeng, Refiloe Examining personal memory in film: A reflection of documenting memory-stories in Reimagining Memories |
| thesis_degree_str | Master's |
| title | Examining personal memory in film: A reflection of documenting memory-stories in Reimagining Memories |
| title_full | Examining personal memory in film: A reflection of documenting memory-stories in Reimagining Memories |
| title_fullStr | Examining personal memory in film: A reflection of documenting memory-stories in Reimagining Memories |
| title_full_unstemmed | Examining personal memory in film: A reflection of documenting memory-stories in Reimagining Memories |
| title_short | Examining personal memory in film: A reflection of documenting memory-stories in Reimagining Memories |
| title_sort | examining personal memory in film a reflection of documenting memory stories in reimagining memories |
| topic | Documentary Arts |
| url | http://hdl.handle.net/11427/39914 |
| work_keys_str_mv | AT mathafengrefiloe examiningpersonalmemoryinfilmareflectionofdocumentingmemorystoriesinreimaginingmemories |