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Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period
Background: Liver biopsy is a fundamental diagnostic tool in clinical hepatology, also playing a crucial role in the prognostication and management of liver diseases. Previous studies at various centres have examined liver biopsies in the context of liver disease workups, including indications, hist...
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| Format: | Thesis |
| Language: | English English |
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Department of Paediatrics and Child Health
2026
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| _version_ | 1867614077998596097 |
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| access_status_str | Open Access |
| author | Mokoto, Tshepang |
| author2 | De Lacy, Ronalda Jacqueline |
| author_browse | De Lacy, Ronalda Jacqueline Mokoto, Tshepang |
| author_facet | De Lacy, Ronalda Jacqueline Mokoto, Tshepang |
| author_sort | Mokoto, Tshepang |
| collection | Thesis |
| description | Background: Liver biopsy is a fundamental diagnostic tool in clinical hepatology, also playing a crucial role in the prognostication and management of liver diseases. Previous studies at various centres have examined liver biopsies in the context of liver disease workups, including indications, histological findings and procedural complications. Objectives: To ascertain the role of liver biopsy in the evaluation of patients with liver diseases at Red Cross War Memorial Children's Hospital (RCWMCH) over a six-year period. Method: This retrospective descriptive study includes all paediatric patients who underwent liver biopsies at RCWMCH between 01/01/2018 and 30/06/2023. Results: Seventy-five patients were screened for eligibility; six were excluded due to missing data and files, subsequently the study comprised of sixty-nine participants. Most liver biopsies were performed percutaneously under ultrasound guidance (n=45, 65%). There were three (4.3%) major complications, and no minor complication. The tissue yield was 95.7% (n = 66), with histopathological findings guiding clinical management in 50 patients (72%). Most frequent diagnoses were biliary atresia and autoimmune hepatitis. The commonest indications for liver biopsy were hyperbilirubinemia and suspected graft rejection. Conclusion: Although liver biopsy is an invasive procedure, if guidelines are adhered to and performed by experienced staff it can be justified when using standard indications as it has a low complication rate in our setting and directly influence management in the majority of cases |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/42661 |
| institution | University of Cape Town (South Africa) |
| language | English eng |
| last_indexed | 2026-06-10T12:46:19.146Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | Department of Paediatrics and Child Health |
| publisherStr | Department of Paediatrics and Child Health |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/42661 Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period Mokoto, Tshepang De Lacy, Ronalda Jacqueline Radebe, Lindokuhle Brown, Robin Liver Red Cross War Memorial Children's Hospital Background: Liver biopsy is a fundamental diagnostic tool in clinical hepatology, also playing a crucial role in the prognostication and management of liver diseases. Previous studies at various centres have examined liver biopsies in the context of liver disease workups, including indications, histological findings and procedural complications. Objectives: To ascertain the role of liver biopsy in the evaluation of patients with liver diseases at Red Cross War Memorial Children's Hospital (RCWMCH) over a six-year period. Method: This retrospective descriptive study includes all paediatric patients who underwent liver biopsies at RCWMCH between 01/01/2018 and 30/06/2023. Results: Seventy-five patients were screened for eligibility; six were excluded due to missing data and files, subsequently the study comprised of sixty-nine participants. Most liver biopsies were performed percutaneously under ultrasound guidance (n=45, 65%). There were three (4.3%) major complications, and no minor complication. The tissue yield was 95.7% (n = 66), with histopathological findings guiding clinical management in 50 patients (72%). Most frequent diagnoses were biliary atresia and autoimmune hepatitis. The commonest indications for liver biopsy were hyperbilirubinemia and suspected graft rejection. Conclusion: Although liver biopsy is an invasive procedure, if guidelines are adhered to and performed by experienced staff it can be justified when using standard indications as it has a low complication rate in our setting and directly influence management in the majority of cases 2026-01-23T10:53:38Z 2026-01-23T10:53:38Z 2025 2026-01-23T07:22:04Z Thesis / Dissertation Masters Masters http://hdl.handle.net/11427/42661 en eng application/pdf Department of Paediatrics and Child Health Faculty of Health Sciences University of Cape Town |
| spellingShingle | Liver Red Cross War Memorial Children's Hospital Mokoto, Tshepang Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period |
| thesis_degree_str | Master's |
| title | Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period |
| title_full | Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period |
| title_fullStr | Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period |
| title_full_unstemmed | Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period |
| title_short | Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period |
| title_sort | review of liver biopsies at red cross war memorial children s hospital over a six year period |
| topic | Liver Red Cross War Memorial Children's Hospital |
| url | http://hdl.handle.net/11427/42661 |
| work_keys_str_mv | AT mokototshepang reviewofliverbiopsiesatredcrosswarmemorialchildrenshospitaloverasixyearperiod |