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Safety of long-term isoniazid preventive therapy in children with HIV
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Public Health and Family Medicine
2014
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| _version_ | 1867613255214563328 |
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| access_status_str | Open Access |
| author | Le Roux, Stanzi Maria |
| author2 | Myer, Landon |
| author_browse | Le Roux, Stanzi Maria Myer, Landon |
| author_facet | Myer, Landon Le Roux, Stanzi Maria |
| author_sort | Le Roux, Stanzi Maria |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6023 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:13.838Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Public Health and Family Medicine |
| publisherStr | Department of Public Health and Family Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6023 Safety of long-term isoniazid preventive therapy in children with HIV Le Roux, Stanzi Maria Myer, Landon Zar, Heather Public Health Includes bibliographical references. Tuberculosis (TB) and HIV co-infection is association with significant morbidity and mortality, especially in young children. Prevention of tuberculosis in children with HIV is a global health priority and is best achieved through a combination of antiretroviral therapy (ART) and isoniazid preventive therapy (IPT). Current WHO guidelines recommend 6 months of IPT for all HIV-infected children older than 1 year without TB disease; up to 3 years is recommended in high TB prevalence areas. Although both ART and IPT can cause liver injury, data on the safety of IPT in HIV-infected children accessing ART is limited, and no published data exist on the hepatotoxicity risk of prolonged IPT. This thesis aims to address these knowledge gaps. 2014-08-05T13:05:08Z 2014-08-05T13:05:08Z 2014 Master Thesis Masters MSc http://hdl.handle.net/11427/6023 eng application/pdf Department of Public Health and Family Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Public Health Le Roux, Stanzi Maria Safety of long-term isoniazid preventive therapy in children with HIV |
| thesis_degree_str | Master's |
| title | Safety of long-term isoniazid preventive therapy in children with HIV |
| title_full | Safety of long-term isoniazid preventive therapy in children with HIV |
| title_fullStr | Safety of long-term isoniazid preventive therapy in children with HIV |
| title_full_unstemmed | Safety of long-term isoniazid preventive therapy in children with HIV |
| title_short | Safety of long-term isoniazid preventive therapy in children with HIV |
| title_sort | safety of long term isoniazid preventive therapy in children with hiv |
| topic | Public Health |
| url | http://hdl.handle.net/11427/6023 |
| work_keys_str_mv | AT lerouxstanzimaria safetyoflongtermisoniazidpreventivetherapyinchildrenwithhiv |