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Towards the total synthesis of novenamine and its analogues with modifications at C-4 and C-5
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
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| _version_ | 1867613292766167040 |
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| access_status_str | Open Access |
| author | Wilson, Seanette Ann |
| author2 | Hunter, Roger |
| author_browse | Hunter, Roger Wilson, Seanette Ann |
| author_facet | Hunter, Roger Wilson, Seanette Ann |
| author_sort | Wilson, Seanette Ann |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6282 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:49.949Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6282 Towards the total synthesis of novenamine and its analogues with modifications at C-4 and C-5 Wilson, Seanette Ann Hunter, Roger Gammon, David W Chemistry Includes bibliographical references. Novenamine, a known antibacterial agent, is composed of 3-0-carbamoyl noviose (novobiose) glycosidically linked to a 4-hydroxy-3-amino-coumarin unit. Its activity as a DNA-gyrase inhibitor and the absence of analogues containing 4-epi-noviose provided the rationale for developing new synthetic routes to these analogues. This thesis describes the total synthesis of the methyl glycosides of noviose and C-4-epi-noviose, methodology for the introduction of the C-3 carbamoyl group to both isomers, an alternative synthesis of the coumarin component, progress towards a C-5 analogue of 4-epi-noviose and a model study of methodology for the glycosidic coupling of the coumarin unit to suitably activated sugars. 2014-08-13T14:25:29Z 2014-08-13T14:25:29Z 2004 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/6282 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Wilson, Seanette Ann Towards the total synthesis of novenamine and its analogues with modifications at C-4 and C-5 |
| thesis_degree_str | Doctoral |
| title | Towards the total synthesis of novenamine and its analogues with modifications at C-4 and C-5 |
| title_full | Towards the total synthesis of novenamine and its analogues with modifications at C-4 and C-5 |
| title_fullStr | Towards the total synthesis of novenamine and its analogues with modifications at C-4 and C-5 |
| title_full_unstemmed | Towards the total synthesis of novenamine and its analogues with modifications at C-4 and C-5 |
| title_short | Towards the total synthesis of novenamine and its analogues with modifications at C-4 and C-5 |
| title_sort | towards the total synthesis of novenamine and its analogues with modifications at c 4 and c 5 |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/6282 |
| work_keys_str_mv | AT wilsonseanetteann towardsthetotalsynthesisofnovenamineanditsanalogueswithmodificationsatc4andc5 |