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Approaches toward the enantioselective total synthesis of amarogentic
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
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| _version_ | 1867613234765234176 |
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| access_status_str | Open Access |
| author | Stevens, Anne Therese |
| author2 | Bull, James R |
| author_browse | Bull, James R Stevens, Anne Therese |
| author_facet | Bull, James R Stevens, Anne Therese |
| author_sort | Stevens, Anne Therese |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6292 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:54.720Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6292 Approaches toward the enantioselective total synthesis of amarogentic Stevens, Anne Therese Bull, James R Chibale, Kelly Chemistry Includes bibliographical references. Three different, but complementary strategies for the enantioselective synthesis of the secoiridoid core of amarogentin were evaluated. The first is based on the enantioselective desymmetrisation of meso-anhydrides using titanium TADDOLates. 1,2,4,6-Tetrahydrophthalic anhydride was desymmetrised and chemoselectively reduced to give (3aR, 7aS)-3a,4,7,7a-Tetrahydro-3H-isobenzofuran-1-one. Further development of this route was performed on a racemic model. 2014-08-13T14:25:53Z 2014-08-13T14:25:53Z 2001 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/6292 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Stevens, Anne Therese Approaches toward the enantioselective total synthesis of amarogentic |
| thesis_degree_str | Doctoral |
| title | Approaches toward the enantioselective total synthesis of amarogentic |
| title_full | Approaches toward the enantioselective total synthesis of amarogentic |
| title_fullStr | Approaches toward the enantioselective total synthesis of amarogentic |
| title_full_unstemmed | Approaches toward the enantioselective total synthesis of amarogentic |
| title_short | Approaches toward the enantioselective total synthesis of amarogentic |
| title_sort | approaches toward the enantioselective total synthesis of amarogentic |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/6292 |
| work_keys_str_mv | AT stevensannetherese approachestowardtheenantioselectivetotalsynthesisofamarogentic |