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Investigations of cellular immune mechanisms to malaria during pregnancy in a malaria holoendemic region of Western Kenya
Bibliography: leaves 132-155.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Immunology
2014
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| _version_ | 1867613219667836928 |
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| access_status_str | Open Access |
| author | Othoro, Caroline |
| author2 | Ryffel, Bernhard |
| author_browse | Othoro, Caroline Ryffel, Bernhard |
| author_facet | Ryffel, Bernhard Othoro, Caroline |
| author_sort | Othoro, Caroline |
| collection | Thesis |
| description | Bibliography: leaves 132-155. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/8597 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:39.476Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Immunology |
| publisherStr | Division of Immunology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/8597 Investigations of cellular immune mechanisms to malaria during pregnancy in a malaria holoendemic region of Western Kenya Othoro, Caroline Ryffel, Bernhard Immunology Bibliography: leaves 132-155. Women during pregnancy in holoendemic regions of malaria are at an increased risk for peripheral malaria infections with potential for developing placental malaria. The immunological basis of protection and pathogenesis are incompletely understood. This thesis investigates both processes. Research on maternal placental immune responses necessitates the collection of reliable placental intervillous blood; an appropriate method for placental blood collection was therefore first determined. Five documented methods of collection (perfusion, incision, biopsy, tissue grinding and prick) were compared for foetal blood contamination and mononuclear cell profiles using flow cytometry. Placental blood collection by prick was established as the most appropriate method and was subsequently used for further immunological investigations. 2014-10-18T05:58:29Z 2014-10-18T05:58:29Z 2003 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/8597 eng application/pdf Division of Immunology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Immunology Othoro, Caroline Investigations of cellular immune mechanisms to malaria during pregnancy in a malaria holoendemic region of Western Kenya |
| thesis_degree_str | Doctoral |
| title | Investigations of cellular immune mechanisms to malaria during pregnancy in a malaria holoendemic region of Western Kenya |
| title_full | Investigations of cellular immune mechanisms to malaria during pregnancy in a malaria holoendemic region of Western Kenya |
| title_fullStr | Investigations of cellular immune mechanisms to malaria during pregnancy in a malaria holoendemic region of Western Kenya |
| title_full_unstemmed | Investigations of cellular immune mechanisms to malaria during pregnancy in a malaria holoendemic region of Western Kenya |
| title_short | Investigations of cellular immune mechanisms to malaria during pregnancy in a malaria holoendemic region of Western Kenya |
| title_sort | investigations of cellular immune mechanisms to malaria during pregnancy in a malaria holoendemic region of western kenya |
| topic | Immunology |
| url | http://hdl.handle.net/11427/8597 |
| work_keys_str_mv | AT othorocaroline investigationsofcellularimmunemechanismstomalariaduringpregnancyinamalariaholoendemicregionofwesternkenya |