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Mathematical models of coreceptor usage and a dendritic cell-based vaccine during HIV-1 infection
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Mathematics and Applied Mathematics
2014
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| _version_ | 1867613271733829632 |
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| access_status_str | Open Access |
| author | Mugwagwa, Tendai |
| author2 | Witten, G |
| author_browse | Mugwagwa, Tendai Witten, G |
| author_facet | Witten, G Mugwagwa, Tendai |
| author_sort | Mugwagwa, Tendai |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/8733 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:28.738Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Mathematics and Applied Mathematics |
| publisherStr | Department of Mathematics and Applied Mathematics |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/8733 Mathematical models of coreceptor usage and a dendritic cell-based vaccine during HIV-1 infection Mugwagwa, Tendai Witten, G Mathematics and Applied Mathematics Includes bibliographical references. While most of Europe is affected by HIV-1 subtype B, sub-Saharan African is dominated by HIV-1 subtype C. Due to costs, most vaccine development is carried out Europe rather than sub-Saharan countries. However since the mechanisms of disease progression in HIV-1 subtype B may be different from those in HIV-1 subtype C, it is interesting to investigate if and how a dendritic cells based vaccine such as the one developed in France and tested on Brazilians (Lu et al, Nature; 2004) can be used on individuals in sub-Saharan Africa. To investigate this, mathematical models and sensitivity analysis techniques are used to understand the mechanisms of disease progression in two HIV-1 subtypes. These models are then extended to explore the ways in which the vaccine could be used to treat these different HIV-1 subtypes. It is found that the level of immune activation plays a large role in determining the mechanism of disease progression and can itself be a means to the development of AIDS. Furthermore, it is also shown that the dendritic cells based vaccine could reduce the viral load but not eliminate the virus resulting in a viral rebound. To maintain a low viral load, vaccination would have to be repeated. Unfortunately, repeated vaccination may lead to the overproduction of proinflamatory cytokines resulting in severe side effects. However this could be avoided by using a carefully planned treatment schedule. We conclude that the dendritic cells based vaccine can be used in individuals in either subtype B or subtype C region as long as the correct treatment schedule is followed. 2014-10-23T07:10:29Z 2014-10-23T07:10:29Z 2005 Master Thesis Masters MSc http://hdl.handle.net/11427/8733 eng application/pdf Department of Mathematics and Applied Mathematics Faculty of Science University of Cape Town |
| spellingShingle | Mathematics and Applied Mathematics Mugwagwa, Tendai Mathematical models of coreceptor usage and a dendritic cell-based vaccine during HIV-1 infection |
| thesis_degree_str | Master's |
| title | Mathematical models of coreceptor usage and a dendritic cell-based vaccine during HIV-1 infection |
| title_full | Mathematical models of coreceptor usage and a dendritic cell-based vaccine during HIV-1 infection |
| title_fullStr | Mathematical models of coreceptor usage and a dendritic cell-based vaccine during HIV-1 infection |
| title_full_unstemmed | Mathematical models of coreceptor usage and a dendritic cell-based vaccine during HIV-1 infection |
| title_short | Mathematical models of coreceptor usage and a dendritic cell-based vaccine during HIV-1 infection |
| title_sort | mathematical models of coreceptor usage and a dendritic cell based vaccine during hiv 1 infection |
| topic | Mathematics and Applied Mathematics |
| url | http://hdl.handle.net/11427/8733 |
| work_keys_str_mv | AT mugwagwatendai mathematicalmodelsofcoreceptorusageandadendriticcellbasedvaccineduringhiv1infection |