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Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis
Includes bibliographical references.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2014
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| _version_ | 1867613341653925888 |
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| access_status_str | Open Access |
| author | Mhlambiso, Zizile |
| author2 | Jackson, Graham Ellis |
| author_browse | Jackson, Graham Ellis Mhlambiso, Zizile |
| author_facet | Jackson, Graham Ellis Mhlambiso, Zizile |
| author_sort | Mhlambiso, Zizile |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/9280 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:36.552Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/9280 Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis Mhlambiso, Zizile Jackson, Graham Ellis Chemistry Includes bibliographical references. It has been shown that copper complexes are able to alleviate inflammation associated with Rheumatoid Arthritis (RA). Serum copper levels are elevated in RA and it has been postulated that endogenous copper might have a protective function in chronic inflammatory conditions. In designing Cu(I1) anti-inflammatory drugs, one needs to know the stability constants of the ligand together with Cu(I1) and the competitive metal ions, Zn(I1) and Ca(I1) in blood plasma. For this purpose glass electrode potentiometry, infrared (lR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, UV/Visible spectroscopy as well as blood plasma modelling were used to explore the coordination chemistry of a newly designed ligand, PCUL (Bis-(3- aminoethy-2-aminomethylpyridine )-oxahexacyclo-dodecane). PCUL protonation and formation constants with Cu(I1) and Zn(I1) were investigated by potentiometric analysis at 2SoC and 0.ISmol/dm3 Na + (CI) The potentiometric analysis showed that CU(I1) formed far more stable complexes at physiological pH with PCUL than the in vivo competitor Zn(I1). In this study the IR spectroscopic analysis was used to determine the Cu(I1)-PCUL complexation sequence. The IR spectra show that the central amines are coordinated to the metal ion first. The small frequency shift between pH 4.02 to 6.91 proves that the pyridyl nitrogen atoms are also coordinated to CU(I1). 2014-11-05T17:41:58Z 2014-11-05T17:41:58Z 2009 Master Thesis Masters MSc http://hdl.handle.net/11427/9280 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Mhlambiso, Zizile Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis |
| thesis_degree_str | Master's |
| title | Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis |
| title_full | Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis |
| title_fullStr | Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis |
| title_full_unstemmed | Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis |
| title_short | Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis |
| title_sort | design of novel copper ii based anti inflammatory drugs for the elevation associated with rheumatoid arthritis |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/9280 |
| work_keys_str_mv | AT mhlambisozizile designofnovelcopperiibasedantiinflammatorydrugsfortheelevationassociatedwithrheumatoidarthritis |