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Clinical indicators of Pneumocystis jiroveci pneumonia (PCP) in South African children infected with human immunodeficiency virus
Includes bibliographical references (leaves 53-60).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Public Health and Family Medicine
2014
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| _version_ | 1867613197783007232 |
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| access_status_str | Open Access |
| author | Fatti, Geoffrey Libero |
| author2 | Swingler, George H |
| author_browse | Fatti, Geoffrey Libero Swingler, George H |
| author_facet | Swingler, George H Fatti, Geoffrey Libero |
| author_sort | Fatti, Geoffrey Libero |
| collection | Thesis |
| description | Includes bibliographical references (leaves 53-60). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/9376 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:18.917Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Public Health and Family Medicine |
| publisherStr | Department of Public Health and Family Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/9376 Clinical indicators of Pneumocystis jiroveci pneumonia (PCP) in South African children infected with human immunodeficiency virus Fatti, Geoffrey Libero Swingler, George H Zar, Heather Public Health Includes bibliographical references (leaves 53-60). Pneumocystis pneumonia (PCP) is an important cause of morbidity and mortality amongst HIV-infected children in Africa. Definitive diagnostic resources for PCP in Africa are limited due to their expense and technical difficulty, however recognising and treating children at risk is essential. As management decisions for children with pneumonia are made primarily on a clinical basis in many African regions, it is important to attempt to define a valid clinical diagnostic technique for PCP that could be used by clinicians to determine the use of correct empirical antibiotic therapy. The objectives of this study were to identify clinical features (associated with PCP in HIV-infected children hospitalised with pneumonia, to determine the combination of features that best predicts PCP in these children, and to calculate the diagnostic accuracy of these features. This study was a re-analysis of a database of a prospective study. Consecutive children below ten years of age, with a primary diagnosis of pneumonia or severe pneumonia, and who were known to be HIV-infected or were suspected of having HIV infection, were included prospectively over a 12 month period. Clinical data and diagnostic testing for PCP were obtained on admission. Bi and multivariate analysis of associations of the clinical variables with PCP were performed using logistic regression, to identify the combination of variables that best predicted PCP. The diagnostic accuracy of the best predicted features were calculated. 2014-11-08T08:06:34Z 2014-11-08T08:06:34Z 2005 Master Thesis Masters MMed http://hdl.handle.net/11427/9376 eng application/pdf Department of Public Health and Family Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Public Health Fatti, Geoffrey Libero Clinical indicators of Pneumocystis jiroveci pneumonia (PCP) in South African children infected with human immunodeficiency virus |
| thesis_degree_str | Master's |
| title | Clinical indicators of Pneumocystis jiroveci pneumonia (PCP) in South African children infected with human immunodeficiency virus |
| title_full | Clinical indicators of Pneumocystis jiroveci pneumonia (PCP) in South African children infected with human immunodeficiency virus |
| title_fullStr | Clinical indicators of Pneumocystis jiroveci pneumonia (PCP) in South African children infected with human immunodeficiency virus |
| title_full_unstemmed | Clinical indicators of Pneumocystis jiroveci pneumonia (PCP) in South African children infected with human immunodeficiency virus |
| title_short | Clinical indicators of Pneumocystis jiroveci pneumonia (PCP) in South African children infected with human immunodeficiency virus |
| title_sort | clinical indicators of pneumocystis jiroveci pneumonia pcp in south african children infected with human immunodeficiency virus |
| topic | Public Health |
| url | http://hdl.handle.net/11427/9376 |
| work_keys_str_mv | AT fattigeoffreylibero clinicalindicatorsofpneumocystisjirovecipneumoniapcpinsouthafricanchildreninfectedwithhumanimmunodeficiencyvirus |