Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Predicting poor outcome Crohn's disease at the time of first diagnosis
Over time, the majority of patients with Crohn's disease (CD) will develop irreversible gastrointestinal (GIT) damage, notably strictures or fistulas, impacting negatively on quality of life and resulting in hospitilisation and surgery. Early and aggressive drug therapy with immunomodulators (IMMs)...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Public Health and Family Medicine
2014
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613244716220418 |
|---|---|
| access_status_str | Open Access |
| author | Watermeyer, Gillian |
| author2 | Myer, Landon |
| author_browse | Myer, Landon Watermeyer, Gillian |
| author_facet | Myer, Landon Watermeyer, Gillian |
| author_sort | Watermeyer, Gillian |
| collection | Thesis |
| description | Over time, the majority of patients with Crohn's disease (CD) will develop irreversible gastrointestinal (GIT) damage, notably strictures or fistulas, impacting negatively on quality of life and resulting in hospitilisation and surgery. Early and aggressive drug therapy with immunomodulators (IMMs) and biologics may alter the likelihood of these complications and improve long-term outcomes. However, this approach is extremely expensive and carries its own battery of side-effects such as infections and malignancy. In addition there are a sizable number of patients with CD who will have a benign disease course and never require potent medical therapies or surgical intervention. As a result, there has recently been a surge of interest in early identification of those people who are at risk of developing complicated disease. The aim of our study was thus to indentify predictive factors for poor outcome CD in a South African setting, in order to select those who would most benefit from early and aggressive medical therapies. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/9420 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:04.194Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Public Health and Family Medicine |
| publisherStr | Department of Public Health and Family Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/9420 Predicting poor outcome Crohn's disease at the time of first diagnosis Watermeyer, Gillian Myer, Landon Public Health and Family Medicine Over time, the majority of patients with Crohn's disease (CD) will develop irreversible gastrointestinal (GIT) damage, notably strictures or fistulas, impacting negatively on quality of life and resulting in hospitilisation and surgery. Early and aggressive drug therapy with immunomodulators (IMMs) and biologics may alter the likelihood of these complications and improve long-term outcomes. However, this approach is extremely expensive and carries its own battery of side-effects such as infections and malignancy. In addition there are a sizable number of patients with CD who will have a benign disease course and never require potent medical therapies or surgical intervention. As a result, there has recently been a surge of interest in early identification of those people who are at risk of developing complicated disease. The aim of our study was thus to indentify predictive factors for poor outcome CD in a South African setting, in order to select those who would most benefit from early and aggressive medical therapies. 2014-11-08T18:08:31Z 2014-11-08T18:08:31Z 2013 Master Thesis Masters MPH http://hdl.handle.net/11427/9420 eng application/pdf Department of Public Health and Family Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Public Health and Family Medicine Watermeyer, Gillian Predicting poor outcome Crohn's disease at the time of first diagnosis |
| thesis_degree_str | Master's |
| title | Predicting poor outcome Crohn's disease at the time of first diagnosis |
| title_full | Predicting poor outcome Crohn's disease at the time of first diagnosis |
| title_fullStr | Predicting poor outcome Crohn's disease at the time of first diagnosis |
| title_full_unstemmed | Predicting poor outcome Crohn's disease at the time of first diagnosis |
| title_short | Predicting poor outcome Crohn's disease at the time of first diagnosis |
| title_sort | predicting poor outcome crohn s disease at the time of first diagnosis |
| topic | Public Health and Family Medicine |
| url | http://hdl.handle.net/11427/9420 |
| work_keys_str_mv | AT watermeyergillian predictingpooroutcomecrohnsdiseaseatthetimeoffirstdiagnosis |