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Immunology and virology of HIV-1 infection in Cameroon
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Virology
2014
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| _version_ | 1867613531734540288 |
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| access_status_str | Open Access |
| author | Tongo Passo, Aime Marcel Simon |
| author2 | Burgers, Wendy |
| author_browse | Burgers, Wendy Tongo Passo, Aime Marcel Simon |
| author_facet | Burgers, Wendy Tongo Passo, Aime Marcel Simon |
| author_sort | Tongo Passo, Aime Marcel Simon |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/9521 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:37:38.188Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Virology |
| publisherStr | Division of Virology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/9521 Immunology and virology of HIV-1 infection in Cameroon Tongo Passo, Aime Marcel Simon Burgers, Wendy Martin, Darren Includes bibliographical references. This study confirms the widespread existence of highly divergent HIV lineages in Cameroon. While the genetic complexity of the Cameroonian HIV-1 epidemic has potentially serious implications for the design of biomedical interventions, detailed analyses of divergent Cameroonian HIV-1 group M lineages could be crucial for dissecting the earliest evolutionary steps in the emergence of HIV-1 group M. In addition, the central nature of HIV-1 consensus M sequences resulted in their broad recognition, but failed to identify highly immunodominant peptides between homogeneous and diverse HIV epidemics. Further refinement of these immunogens may contribute to the development of a globally relevant vaccine. Finally, the use of PTE peptides did not increase the breadth of T cell recognition in Abstract Page xvi this divergent population when compared to consensus M peptides. This underlies the need to include more mosaic peptides representing the variety of viruses that circulate in the region. 2014-11-11T06:49:55Z 2014-11-11T06:49:55Z 2014 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/9521 eng application/pdf Division of Virology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Tongo Passo, Aime Marcel Simon Immunology and virology of HIV-1 infection in Cameroon |
| thesis_degree_str | Doctoral |
| title | Immunology and virology of HIV-1 infection in Cameroon |
| title_full | Immunology and virology of HIV-1 infection in Cameroon |
| title_fullStr | Immunology and virology of HIV-1 infection in Cameroon |
| title_full_unstemmed | Immunology and virology of HIV-1 infection in Cameroon |
| title_short | Immunology and virology of HIV-1 infection in Cameroon |
| title_sort | immunology and virology of hiv 1 infection in cameroon |
| url | http://hdl.handle.net/11427/9521 |
| work_keys_str_mv | AT tongopassoaimemarcelsimon immunologyandvirologyofhiv1infectionincameroon |