Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Metal ion equilibria in biofluids - copper and rheumatoid arthritis
Includes bibliographies.
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613547194744832 |
|---|---|
| access_status_str | Open Access |
| author | Kelly, Mark Joseph |
| author2 | Graham, Jackson |
| author_browse | Graham, Jackson Kelly, Mark Joseph |
| author_facet | Graham, Jackson Kelly, Mark Joseph |
| author_sort | Kelly, Mark Joseph |
| collection | Thesis |
| description | Includes bibliographies. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/9584 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:37:52.932Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/9584 Metal ion equilibria in biofluids - copper and rheumatoid arthritis Kelly, Mark Joseph Graham, Jackson Chemistry Includes bibliographies. A computer model of blood plasma has been used to evaluate the factors affecting the ability of a ligand to increase the low molecular weight copper pool in vivo. The justification for using this speciation approach is based on the assumption that the low molecular weight copper complexes are important in the reduction of the inflammation associated with rheumatoid arthritis. Based on the results of the simulation, two novel ligands, 3,6,9, 12-tetra-azatetradecanedioic acid (dtda) and 3,6,9,-triazaundecanedioic acid (dtda) have been synthesised using a three step route. Multiple carboxylation was prevented by using the tosylate protecting group. The compounds were obtained in an overall yield of 14.7 and 29.0 , respectively, and characterised using n.m.r, l.R. and mass spectrometry. The stability constants of the complexes formed by these ligands with several metal-ions were determined using glass electrode potentiometry at 25°C and an ionic strength of 0.15 mol dm3. The metals used were the divalent ions of magnesium, calcium, manganese, cobalt, nickel, copper and zinc. The values determined followed the Irvine-Williams order of stability. 2014-11-11T20:18:31Z 2014-11-11T20:18:31Z 1998 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/9584 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Kelly, Mark Joseph Metal ion equilibria in biofluids - copper and rheumatoid arthritis |
| thesis_degree_str | Doctoral |
| title | Metal ion equilibria in biofluids - copper and rheumatoid arthritis |
| title_full | Metal ion equilibria in biofluids - copper and rheumatoid arthritis |
| title_fullStr | Metal ion equilibria in biofluids - copper and rheumatoid arthritis |
| title_full_unstemmed | Metal ion equilibria in biofluids - copper and rheumatoid arthritis |
| title_short | Metal ion equilibria in biofluids - copper and rheumatoid arthritis |
| title_sort | metal ion equilibria in biofluids copper and rheumatoid arthritis |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/9584 |
| work_keys_str_mv | AT kellymarkjoseph metalionequilibriainbiofluidscopperandrheumatoidarthritis |