Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment
Includes bibliography.
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613244616605696 |
|---|---|
| access_status_str | Open Access |
| author | Swan, Paul Lombard |
| author2 | Egan, Timothy J |
| author_browse | Egan, Timothy J Swan, Paul Lombard |
| author_facet | Egan, Timothy J Swan, Paul Lombard |
| author_sort | Swan, Paul Lombard |
| collection | Thesis |
| description | Includes bibliography. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/9782 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:04.194Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/9782 Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment Swan, Paul Lombard Egan, Timothy J Koch, Klaus Chemistry Includes bibliography. To establish their potential as a template for novel anti-malarial drugs, a series of planinum (II) complexes were synthesised, their association with haematin determined in 40 aqueous DMSO, pH 7.4 at 25°C and their ability to inhibit the formation of β-haematin (synthetic malaria pigment) was investigated. The compounds synthesised and investigated contained a platinum (II) ion coordinated to acylthiourea and diimine ligands. The diimines used included both substituted and unsubstituted 2,2’-bipyridines and 1,10-phenanthrolines. 2-phenyl pyridine was also utilised as a ligand. It has been shown that the uncoordinated planar ligands interact weakly with haematin with a log K in the range of 1.9 and 3.3 while the twisted or more sterically hindered ligands show no observable association with porphyrin. A series of complexes having platinum coordinated which was reflected in association constant log K values in the range of 4.8 to 5.8. Using a 1,10-phenanthroline ligand in place of a 2,2-bipyridine ligand increased the association constant of the platinum complex, resulting in this series of complexes having log K values in the range of 5.8 to 6.2. It has been shown that when platinum (II) is coordinated to diimines, it is the electron withdrawing properties of the metal which result in the strong association between the diimine containing complex and haematin. Finally both the complex containing platinum cis to two acylthiourea ligands as well as a platinum complex containing 2-phenyl pyridine were shown to have no observable interaction with haematin. 2014-11-22T05:52:48Z 2014-11-22T05:52:48Z 2002 Master Thesis Masters MSc http://hdl.handle.net/11427/9782 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Swan, Paul Lombard Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment |
| thesis_degree_str | Master's |
| title | Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment |
| title_full | Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment |
| title_fullStr | Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment |
| title_full_unstemmed | Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment |
| title_short | Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment |
| title_sort | synthesis of mixed ligand water soluble square planar platinum ii complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/9782 |
| work_keys_str_mv | AT swanpaullombard synthesisofmixedligandwatersolublesquareplanarplatinumiicomplexesandaninvestigationoftheirassociationwithhaematinandpotentialtoinhibittheformationofsyntheticmalariapigment |